Kym Faull, Ph.D

The technique of mass spectrometry is used for the structural determination and quantification of a wide variety of organic and inorganic compounds. The unique power of the technique comes from the accuracy with which molecular weights of molecules can be measured. These measurements can be made over a vast range of compounds types (from drugs to proteins, for example from cocaine to albumin), presented in any form (solids, solutions and gases) and in impure states (eg. in extracts of body fluids or tissues). These measurements can be made on miniscule amounts of material.

Recent and Selected Publications

Whelan, S.A., Lu, M., He, J., Yan, W., Saxton, R., Faull, K.F., Whitelegge, J.P., and Chang, H. (2009) Mass spectrometry (LC-MS/MS) site-mapping of N-glycosylated membrane proteins for breast cancer biomarkers. J. Proteome Res. 8: 4151-4160. PMID: 19522481. PMCID: PMC2761014.

Kern, J., Ryan, C., Faull, K., and Schneewind, O. (2010) Bacillus anthracis surface-layer proteins assemble by binding to the secondary cell wall polysaccharide in a manner that requires csaB and tagO. J. Mol. Biol. 401: 757-775. PMID: 20603129.

Halgand, F., Zabrouskov, V., Bassilian, S., Souda, P., Wong, D.T., Loo, J.A., Faull, K.F., and Whitelegge, J.P.  (2010) Micro-heterogeneity of human saliva Peptide P-C characterized by high-resolution top-down Fourier-transform mass spectrometry. J. Am. Soc. Mass. Spectrom. 21: 868-877. PMID: 20185333.

Shaw, B.F., Moustakas, D.T., Whitelegge, J.P., Faull, K.F. (2010) Taking charge of proteins from neurodegeneration to industrial biotechnology. Adv. Prot. Chem. Struct. Biol. 79:127-164. PMID: 20621283.

Tsirulnikov, K., Abuladze, N., Koag, M.-C., Newman, D., Scholz, K., Bondar, G., Zhu, Q., Avliyakulov, N.K., Dekant, W., Faull, K., Kurtz, I., and Pushkin, A. (2010) Transport of N-acetyl-S-(1,2-dichlorovinyl)-L-cysteine, a metabolite of trichloroethylene, by mouse multidrug resistance associated protein 2 (Mrp2). Toxicol. Appl. Pharmacol. 244: 218-225. PMID: 20060011. PMCID: PMC2847015.